When
Speech must remain understandable while steady noise is reduced.
Then
Compare the original and isolated speech at the same listening volume.
A louder result can seem clearer even when the voice isolator has removed quiet syllables. Listen for word endings and changes in tone, not just a quieter gap between sentences.
When
Another person speaks at the same time as your subject.
Then
Test a short overlapping passage before processing the whole file.
Both speakers occupy similar vocal territory. Separation may leave pieces of the other voice or weaken the one you want, so an online example with simple background hum is not a reliable prediction.
When
Music or ambience belongs in the finished edit.
Then
Keep the original mix alongside any isolated voice track.
An isolated track is useful for editing dialogue, but it may sound unnatural alone. Blending it cautiously with the original can preserve the setting without putting the noise back at full strength.